All I can say is that I've never actually finished the second half of Earthbound and this comic reminded me of that. Maybe one of you forumites can back me up here and put down something more substantial.
Also, can't say I've ever quite run into the problem that Bear described in "Bunny vs. Ogre." Though the closest I've come was one time where I had one of those "Passport" portable hard drives and put it in my backpack. Then later when I took it out to use it I heard the "click of death." At least there were no immediate files I needed from that thing, but it taught me the value of buying a protective case for my next one. It hasn't stopped me from absent-mindedly losing flash drives though. That's probably impossible.